منابع مشابه
Cytokines and the lung.
Cytokines are signal molecules that induce movement, differentiation, growth and death of many cell types. Cytokines generate these effects through interactions with receptors, which relay a signal into the cell triggering a response. Cytokine-receptor interactions are promiscuous; a combining site of any receptor can bind many ligands. Promiscuity allows for the generation of agonists, alterna...
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The cellular and cytokine network that regulates the human IgE synthesis has recently been clarified. In contrast to intracellular bacteria, that induce the activation of helper T cells producing IFN-,, but not IL-4 (WH cells), allergens and helminths preferentially activate helper T cells that produce IL-4, but not IFN-, (TH cells). TH cells provide the B cells with both signals (T/B cell cont...
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Idiopathic pulmonary fibrosis (IPF) exhibits a complex and poorly understood pathogenesis. Overt inflammation in the lungs of patients with established IPF is absent, and classic anti-inflammatory therapies are inefficacious; however, inflammation may contribute to the disruption of the normal alveolar architecture, allowing interaction between fibroblasts and the epithelium. The polarisation o...
متن کاملMechanical Ventilation–induced Lung Release of Cytokines
A Key for the Future or Pandora’s Box? IN this issue of ANESTHESIOLOGY, Whitehead et al. bring experimental evidence suggesting that a high tidal volume ventilation can markedly reduce the release of inflammatory cytokines in response to intratracheal lipopolysaccharide. They attribute this paradoxical effect to a reduction of the alveolar macrophage population and hypothesize that injurious ve...
متن کاملLung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy
Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2001
ISSN: 0000-0000,0903-1936
DOI: 10.1183/09031936.01.00266001